2 Methods

The development of evidence-based clinical practice guidelines that meet NHMRC standards involves developing a set of clinical research questions, systematically reviewing the scientific literature for evidence related to those questions, and then developing and grading recommendations based on a structured assessment of the evidence.12 The methods used in applying this process to the development of this module are outlined below, and are given in full in the accompanying technical reports. A summary of the overall process for development of this module is given in Appendix D.